Abstract

A REVIEW ON PRONIOSOME, A PROMISING CARRIER FOR DELIVERY OF DRUG ACROSS MEMBRANES

Ramandeep Kaur*, Meenu Nagpal, Rupinder Sidhu, Sukhdev Singh,
Upendra Kumar Jain

ABSTRACT

Proniosomes a novel drug carrier preparation for producing a dry product which may be hydrated immediately before use to yield aqueous niosome dispersions. These ‘proniosomes’ minimize problems of niosome physical stability such as aggregation, fusion and leaking, and provide additional convenience in transportation, distribution, storage and dosing. This report describes the preparation of dispersions of proniosome-derived niosomes, comparison of these niosomes to conventional niosomes, and optimization of proniosome formulations. Conventional and proniosome-derived niosomes are compared in terms of their morphology, particle size, particle size distribution, drug release performance in synthetic gastric or intestinal fluid. The latest approach in the field of vesicular delivery is to combine the two previously mentioned techniques by extending the pro-vesicular approach to niosomes through the formation of ‘‘proniosomes.”

Keywords: proniosomes, niosomes, particle size.