Abstract

FORMULATION AND OPTIMIZATION OF SALBUTAMOL SULPHATE ENCLOSED IN ALGINATE MICROBEADS PREPARED BY IONOTROPIC GELATION METHOD

Indhumathi D*, Mohan Varma, Nagirey R.C.Reddy, Pydimarry. Nikhil,
Pranuthi Anandaraj

ABSTRACT

Oral route is the most convenient and common mode of administration of controlled release system. Microbeads is at present most common and rapidly expanding technology for controlled drug delivery system. Salbutamol sulphate is a beta2-adrenergic, anti-asthmatic drug used as bronchodilator in the treatment of bronchial asthma. The major drawback is its shorter biological half life of 4.5 hrs and needs frequent dosing of 2-3 times daily, causing patient non-compliance. To overcome this drawback, an attempt has been made to develop an oral sustained release dosage form of salbutamol sulphate microbeads. It is prepared by ionotropic gelation method, enclosed in sodium alginate as the hydrophilic carrier in combination with pectin and guar gum as coated polymers to modify the drug release. The results shows Salbutamol sulphate release from microbeads formulated with sodium alginate and guar gum (0.5 &1%w/v) coating polymers F8 showed a satisfactory sustained release profile compared to all the formulations. F8 containing all the polymers such as sodium alginate, guar gum and pectin shows a very good extended dissolution profile of 89.76% at 9th hour.

Keywords: Microbeads, ionotropic, sodium alginate, guar gum.