Abstract

A REVIEW ARTICLE : ON NANOEMULSION

Raj Kumar Mishra*, G.C.Soni, R.P Mishra

ABSTRACT

Nanoemulsions have the potential in pharmaceutical industries because of the transparency at high droplet volume fraction, higher rate of bioavailability or diffusion and increased shelf life of the pharmaceuticals. Nanoemulsions are clear, thermodynamically stable, isotropic liquid mixtures of oil, water, surfactant and co-surfactant. These are oil-in-water (o/w) type of emulsions with the average droplet size ranging from 5nm to 100 nm. Reduction in droplet size to nanoscale leads to change in physical properties such as optical transparency & unusual elastic behavior. Nanoemulsions/ Sub-micron emulsions (SMEs)/ Mini-emulsions are thermodynamically stable transparent or translucent dispersions of oil and water stabilized by an interfacial film of surfactant and co surfactant molecules having a droplet size of less than 100 nm. This review provides brief information about method of preparation and evaluation of nanoemulsion as drug carriers for improving the delivery of therapeutic agents. several techniques are to be used for preparation of nanoemulsions like microfluidization, high pressure homogenization, low energy emulsification and solvent evaporation method and parameter that are to be used for its characterization like droplet size analysis, viscosity determination, drug content, refractive index, pH, zeta potential, Transmission electron microscopy, thermal stability, release and in vitro skin permeation study.

Keywords: Nanoemulsion, Poorly soluble drug, Characterization, Application.