Abstract

A REVIEW ON FORMULATION AND EVALUATION FOR MOUTH DISSOLVING TABLET

Uma Shankar Mishra*, Dr.S.K.Prajapati, Dr.P.Bhardwaj

ABSTRACT

Mouth dissolving tablets are gaining more prominence as a novel drug delivery system & emerges as one of the popular & widely accepted dosage forms, especially for pediatric patients because of incomplete development of muscular & nervous system & in case of geriatric patients suffering from Parkinson’s disorder or hand tremors, forms like tablets and capsules are now days facing the problems like dysphagia, resulting in the highincidence of non compliance and making the therapy ineffective. from both pharmaceutical industries as well as patients because they are convenient to be manufactured & administered, free of side effects, offering immediate release & enhance bioavailability , so as to achieve better patient compliance. One such problem can be solved in the novel drug delivery system by formulating “mouth dissolving tablets” (MDTs) which disintegrates or dissolves rapidly without water with in few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. To obviate the problems associated with conventionaldosage forms, mouth dissolving tablets have been developed having good hardness, dose uniformity, easy administration andserves as the first choice of dosage form for paediatrics, geriatrics and travelling patients. The MDTs were developed with an aim of having sufficient hardness, integrity and faster disintegration without water. Fast dissolving Tablets are disintegratingand/or dissolve rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkablyfast, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fast-disintegrating tablets, as they may take up to a minuteto completely disintegrate

Keywords: Mouth dissolving tablet, Patented technologies, Fast Dissolving, Rapid Disintegration.