Abstract

SOLID DISPERSION INCORPORATED GEL SYSTEM: A NOVEL APPROACH IN TRANSDERMAL DRUG DELIVERY.

S. A. Ghuge*, A. B. Darekar, R.B. Saudagar

ABSTRACT

Solid dispersion incorporated gel is the unique approach in topical drug delivery system to enhance the in vitro transdermal penetration of poorly soluble drugs. This article reviews preparation technique for solid dispersion incorporated gel as a recent and newer technology for transdermal drug delivery system. Drug Penetration through the skin in gel form is depends upon the aqueous solubility of drug. Drug insolubility is one of the formulation barrier and Solid dispersion is favorable approach to improve solubility and bioavailability of poorly soluble drugs. It refers as dispersion of active ingredient in different carriers like-cyclodextrin, PEG, PVP, Sodium lauryl sulphate (SLS) and Urea at determined concentration. Gels are semisolid polymeric matrix system in which drug is dispersed in different polymers like carbomer, HPMC, polaxomer and natural gums. Solid dispersion of drug is incorporated in gel, of suitable polymer with trituration to get homogenous dispersion of drug in gel. The resulting solid dispersion incorporated gel is characterized for various physicochemical parameters like, pH, drug content, spreadability, viscosity, extrudability, and in vitro drug release. Solid dispersion incorporated gel is the safe and effective way of treatment for poorly soluble drugs used in management of different diseases.

Keywords: Solid dispersion incorporated gel, Insolubility, topical delivery.