Abstract

A NOVEL BIODEGRADABLE MICROPARTICULATED DRUG DELIVERY SYSTEM: ON REVIEW

Mr. Manish Kumar Gupta*, Dr. Deepak Prakash, Dr. Brahmeshwar Mishra

ABSTRACT

A well designed controlled drug delivery system can overcome some of the problems of convention therapy and enhance the therapeutic efficacy of a given drug. There are various approach in delivering a therapeutic substance to target site in a sustained controlled release manner. Targeting of drug to the particular site is an important aspect of drug delivery system. One such approach is using biodegradable microparticles as delivery for various drugs. This review presents the outstanding contributions in the field of biodegradable microparticulate system used as drug delivery systems including process technology for preparation of microparticles, drug release systems with drug release mechanism and the most important past, current and future strategies using drug loaded microparticles to improve the efficiency of various medical treatments. There are a number of techniques available for microencapsulation of drugs for Microparticle formulations such as the emulsion solvent evaporation/extraction method, spray drying, milling of films, and solvent extraction/evaporation methods, phase separation-coacervation, interfacial deposition, and in situ polymerization. There are several methods are available for drug release but current methods fall into three broad categories, viz., dialysis bag diffusion, sample & separate, and flow through cell technique. The review embraces various aspects of microparticle application in delivery of drug molecules and therapeutic genes.

Keywords: Microparticles, Microencapsulation, Process technology of Microparticles, Drug Release Profile.