Abstract

ANTHELMINTIC ACTIVITY OF EXTRACTS OF HOLARRHENA ANTIDYSENTERICA WALL

Kranti Satpute*, Kaumudee Bodas, Varsha Shende, Wajid Chaus, Dhumal Atul, Galphade Amar

ABSTRACT

Background: Helminthes have been common cause of concern and pose many problems to human beings and animals. Many medicinal plants claimed to possess anthelmintic activity and can be effectively used against these types of disorders. Holarrhena Antidysenterica, commonly called Kurchi bark is deciduous shrub belonging to Apocynaceae was traditionally used to treat Helminthiasis. Objective: To test Anthelmintic activity of aqueous and alcoholic extracts of Holarrhena Antidysenterica.. Materials and Methods: Indian adult earthworms (Pheretima posthuma) were used to study anthelmintic activity. The activity was checked in aqueous and alcoholic bark extracts at three different concentration (10, 20 and 40mg/ml) and results were expressed in terms of paralysis time and death time for worms. The results were compared with standard solution, Albendazole (10, 20 and 40mg/ml). Results: Both the extract showed significant anthelmintic activity. The effect was dose dependant and shortest time taken for paralysis and death was observed in case of alcoholic extract at 40 mg/ml concentration. Conclusion: It was concluded that seeds of Holarrhena Antidysenterica have potential anthelmintic activity.

Keywords: Anthelmintic, Holarrhena Antidysenterica, Alcoholic extrct, aqueous extract