Abstract

ASSESSMENT OF SERUM LEVEL OF CALCIUM AND PHOSPHORUS IN SUDANESE PATIENTS WITH HYPERTHYROIDISM

Rooa M.Eltayeb, Nassr Eldin M.A Shrif, Elhashimi E. Hassan*

ABSTRACT

ABSTRACT Background: Thyroid hormones play an important role in homeostasis of Calcium and Phosphorous levels by their direct action on bone turnover. The importance of this study was that the thyroid hormones inter in calcium & phosphorous metabolism and it frequently disturbed in hyperthyroidism. It is very important to monitor changes in the levels of serum calcium & phosphorous in hyperthyroidism. Objective: this study was aimed to assess the association between thyroid hormones and macro metals calcium and phosphorus in Sudanese patients with hyperthyroidism in comparison with apparently healthy controls. Material and method: A clinical-based descriptive, analytical study was conducted during the period from September 2013 to march 2014. Fifty patients with Hyperthyroidism (25 males and 25 females) were selected as a test group compared with a control group which included 50 apparently healthy volunteers (25 males and 25 females), patients and controls were from Khartoum Teaching Hospital in Khartoum state, Sudan. Blood specimens were collected from both groups and serum levels of Ca, PO4, TSH, T3 andT4 were estimated. Age and gender of the test group were matched with the control group. Result: the mean of serum levels of Calcium and phosphorus in hyperthyroidism patients (10.00± 0.808), (4.332± 0.8029) was significant increased than control groups (9.06± .466), (3.600± 0.399) respectively. (p <0.001). The prevalence of hypercalcemia was 38% in hyperthyroidism patients. In hyperthyroidism serum calcium & phosphorus was negatively correlated with the duration of hyperthyroidism, while was not correlate with age & gender. Conclusion: the serum calcium & phosphorous levels are significantly altered in hyperthyroidism. That may increased risk for secondary osteoporosis and bone fractures so hyperthyroidism patients should be monitored regularly in order to delay or minimize the development of complication.

Keywords: Calcium, Phosphorus, Hyperthyroidism, Thyroid stimulating hormone, Thyroxin and Tri-Iodothyronine.