Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF SOME METAL COMPLEXES DERIVED FROM BENZOFURAN SCHIFF’S BASE.

M. B. Halli*, K. Mallikarjun , S. S. Suryakanth and P. Vithal Reddy

ABSTRACT

Novel Schiff base and its metal complexes have been synthesized via the condensation of Benzofuran-2-carbohydrazide and 2-hydroxy-3- formylquinoline. The synthesized Schiff’s base and complexes were characterized on the basis of elemental analysis, UV-Vis, IR, 1HNMR, ESR and Mass spectral studies. All the complexes are soluble in DMF and DMSO. The measured molar conductance values suggest that the complexes are non-electrolytic in nature. We propose the octahedral geometry for Co(II), Ni(II) and Cu(II) complexes, based on spectral data, magnetic data and analytical data. The Cd(II), Zn(II) and Hg(II) complexes show the tetrahedral geometry. The Schiff base and their metal complexes were screened for their anti-bacterial, anti-fungal and DNA cleavage activity studies. The result show that the biological activity of the ligand gets increased on complexation. DNA cleavage studies shows the complexes have displayed complete cleavage of CT-DNA. In addition the ligand and its complexes has been studied for their antioxidant activity.

Keywords: Benzofuran, Quinoline, Schiff base, Metal complexes, Spectral studies, DNA cleavage. Antioxidant activity.