PHYTOCHEMICAL SCREENING AND EVALUATION OF ANALGESIC, ANTI-INFLAMMATORY ACTIVITY OF ALCOHOLIC EXTRACT OF JASMINUM SAMBAC ON ALBINO RATS
*B.Rambabu, K.S.K Rao Patnaik
ABSTRACT
The methanol extract of its flowers was investigated for its antiinflammatory
and analgesic activities in animal models. The alcoholic
extract at 400 mg/kg body weight reduced significantly the formation
of oedema induced by carrageenan. In the acetic acid-induced writhing
model, the extract and the fractions had a good analgesic effect
(P<0.01) characterized by a reduction in the number of writhes when
compared to the control. These results were also comparable to those
of Diclofenac sodium, the reference drug used in this study. Acute
toxicity test showed that the plant may be safe for pharmacological
uses. This study has provided some justification for the folkloric use of
the plant in several communities for conditions such as pain and
inflammations.
Keywords: Jasminum sambac, Analgesic activity, anti-inflammatory activity, Dimethyl sulfoxide, Eddy’s hot plate plethysmometer.
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