Abstract

EFFICACY OF HYPERICUM HOOKERIANUM IN REVERSING THE SYMPTOMS OF HALOPERIDOL INDUCED TARDIVE DYSKENESIA, CATATONIA AND CATALEPSY IN SWISS ALBINO MICE - BEHAVIOURAL ANALYSIS REPORT

Uma Devi Pongiya*, Badarunnisa Mohammed Kandanath, Yalaga Rama Rao, Mohammed RafiqKhan and Subakanmani.S

ABSTRACT

With its hallucinations, delusions, thought disorder, and cognitive deficits, schizophrenia affects the most basic human processes of perception, emotion, and judgment. Haloperidol (HP) is a first generation antipsychotic frequentlyused in the treatment of schizophrenia. It is adrug of the butyrophenone class of neurolepticsUsage of haloperidol is limited by the drug’s tendencyto exhibit a range of extra-pyramidal symptoms such as and tardive dyskinesia and catalepsy. Tardive dyskinesiais a serious neurological syndrome associated withthe chronic use of neuroleptics. Such patients presentwith symptoms such as involuntary lip smacking, sucking or chewing and facial grimacing. Tardive dyskinesia may persist for months or years despite withdrawal and may beirreversible. Catalepsy is a condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. The exact pathophysiology of haloperidol-induced catalepsy and Tardive dyskinenesia has yet to be elucidated. Since hypericum species are having very good neuro protective potential, Ethanolic extract from aerial parts of Hypericum hookerianum was investigated for the first time for its efficacy for reversingthe symptoms of tardive dyskenesia, catatonia and catalepsy by behavioral analysis in swiss albino mice. Haloperidol was administered to mice (2.5mg/kg i.p -0.4ml from the prepared stock solution) for a period of 21 days to. All the behavioral assessment were carried out 24 h after the last dose of haloperidol. The behavioral assessments were observed on 2nd, 7th,14th,and 22nd day of treatment with Haloperidol. Ethanolic extract of hypericum hookeranium (EEHh) at a dose of 200mg/kg and 400 mg/kg treated groups were compared with Haloperidol treated group.Results showed that this plant has efficiency in diminishing the catalepsy and tardive dyskinenesia side effects and behaviuoral impairements in HAL induced animals.

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