Abstract

FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF CINNARIZINE BY DIRECT COMPRESSION METHOD

A.K.Dhadwe*, C.P.Rathod, S.M.Vadvalkar, N.B.Ghiware, N.Y.Gond,G.R. Shendarkar, P. K. Sahoo

ABSTRACT

In the present work, oral dispersible tablets of cinnarizine were prepared by direct compression method with a view to enhance safety and efficacy of drug molecule as well as to achieve better patient compliance. The objective of this study was to develop Orodispersible tablets of Cinnarizine with increased rate of dissolution may leads to increase bioavailability. Indion 414, Polyplasdone XL, Ac-di-sol and Primojel were used as Superdisintegrants on account of their well established production technology by direct compression. Cinnarizine is the most effective drug for management of motion sickness which is selective calcium antagonist, Anti-Allergic Agents and H1 receptor antagonist. Cinnarizine is having short biological half-life (2.5hr), high first-pass metabolism and oral bioavailability (15%) and (96%) S.C.The prepared tablets were evaluated for thickness, uniformity of weight, content uniformity, hardness, tensile strength, porosity, friability, wetting time, water absorption ratio, In-vitro and In-vivo disintegration time within 10 to 16 s and12 to 18 s, respectively and In-vitro drug release, almost 90 percent of drug was released from all formulations within 10 min. Drug content was estimated spectrophotometrically at 254 nm.DSC & IR spectral analysis the pure drug characteristic absorption bands and formulations absorption bands have shown all most same range. It was concluded that superdisintegrants addition technique is a useful method for preparing oral dispersible tablets by direct compression method.

Keywords: Orodispersible tablet; direct compression, Cinnarizine; Indion 414, Polyplasdone XL, Ac-di-sol, Primojel, Motion Sickness