Abstract

ANTIHYPERGLYCEMIC AND BIOCHEMICAL EVALUATION OF HYDROALCOHOLIC EXTRACT OF CAESALPINIA BONDUCELLA LEAVES

Fahad I.Al-Saikhan, Sudarsini Saravanabhavan*,

ABSTRACT

Diabetes mellitus is a common disorder associated with markedly increased morbidity and mortality rates, which affect a large number of people around the globe, can be defined as a group of metabolic diseases characterised by chronic hyperglycaemia that results from defects in insulin secretion, insulin action, or both, and causes impaired function in carbohydrate, lipid, and protein metabolism. Diabetes was induced in male Wistar albino rats by alloxan monohydrate. Animals were randomly divided into 6 groups (1, normal control, 1 diabetic control and 4 treated groups). Control animals received saline (5 mL/kg) orally, whereas the treatment groups received different doses of Caesalpinia bonducella leaves (100, 200, and 400 mg/kg), Glibenclamide (4 mg/kg) was administered orally once a day for 14 days. Blood was withdrawn for glucose determination on the 1st, 6th, 10th, and 14th days. The rats were fasted overnight and then sacrificed on the 14th day; blood was collected for biochemical evaluation, including the levels of blood glucose. Administration of Caesalpinia bonducella leaves in alloxan-induced diabetic rats significantly reduced blood glucose when compared with the control group. The results suggested that Caesalpinia bonducella leaves exhibits antidiabetic effects in alloxan-induced diabetic rats.

Keywords: Caesalpinia bonducella, Diabetes mellitus, alloxan monohydrate Glibenclamide.