ANTIDIABETIC POTENTIAL OF SOLANUM XANTHOCARPUM SCHRAD. AND WENDL. IN STZ-NICOTINAMIDE INDUCED DIABETIC RATS
Anitha Mary Mathews*, Christina AJM
ABSTRACT
Solanum xanthocarpum is a plant that belongs to solanaceae family
with many therapeutic applications in traditional systems of medicine
especially Ayurveda.The ability of the plant to promote glucose uptake
was studied by the communicating author in an in vitro model using L6
skeletal muscle cell lines.The aerial parts and fruit of the plant were
found to augment uptake of glucose by GLUT-4,which was indicative
of increased insulin sensitivity or insulin-like activity or both. The
present study was aimed at investigating the in-vivo antidiabetic
potential of Solanum xanthocarpum Schrad.&Wendl, and to elucidate
its probable mechanism of action.The ethanolic extracts of the aerial
parts and fruit of the plant,at the dose of 400mg/kg produced significant reduction in elevated
blood glucose level by the 28th day of STZ-induced diabetes. Intraperitoneal administration
of nicotinamide in the dose of 230mg/kg prior to the administration of STZ produced partial
destruction of beta cells that resembled type 2 diabetes.Administration of test extracts
produced a corresponding increase in insulin level and reduction in HbA1c ,CK and LDH
values.The animals gained weight during the course of treatment.
Keywords: aerial parts, fruit, Solanum xanthocarpum,STZ –NAD.
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