DESIGN AND DEVELOPMENT OF ORODISPERSIBLE TABLETS OF TADALAFIL USING NOVEL SUPERDISINTEGRANTS
Mayur H. Patil*, Dr Surajj Sarode, Dr. P. V. Jain, Prof. B. S. Sathe, B. V. Jain, Dr. G.P. Vadnere
ABSTRACT
The present work aimed at preparing oro-dispersible tablets of
Tadalafil with the purpose of developing a dosage form for a very
quick onset of action, which is very convenient for administration,
without the problem of swallowing and using water. The tablets of
tadalafil was prepared by using superdisintegrants like sodium starch
glycolate, Indion 234s, Indion 234 as an ion exchange resins by direct
compression method. The formulated fast dissolving tablets were
evaluated for physical characteristics such as Hardness, thickness
,uniformity of weight, drug content uniformity, Invitro disintegration
and invitro dissolution .The formulations were subjected to disintegration, In-vitro drug
release tests. The FTIR and DSC studies revealed that no physicochemical interaction
between excipients and drug. Fast dissolving tablets of tadalafil containing combination of
SSG and Indion 234s as superdisintegrant showed (94.33%) drug release within 10min.
Percentage content uniformity (99.20%). Fast dissolving tablets of Tadalafil can be
considered suitable for clinical use in the treatment of Erectile Dysfunctioning.
Keywords: Tadalafil , Indion 234, Indion 234s, Direct comprssion method.
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