Abstract

ANTI ULCER ACTIVITY OF CARISSA CARANDAS USING ROOT EXTRACT IN ALBINO RATS

Ankit H Merai*, Anil G Jadhav

ABSTRACT

From the past few years there is increasing research interest on the natural compounds, due to their wide variety of pharmacological activities. The main aim of the present study was to evaluation anti ulcer activity of Carissa Carandas. For gastric ulcer many marketed products are available like Cimetidine, Famotidine, Ranitidine, Sucralfate, Prostaglandins, Omeprazole, Anticholinergics but many case studies shows that they having many major side effects likes; PPIs having higher risk of fracture, alter the iron absorption and causes iron deficiency anaemia, risk of vitamine B12 deficiency. Both H2 receptor antagonist and Proton Pump Inhibitors have major effect on cardiac system it’s prolong atrioventricular conducting time, sinus arrest, sinus bradycardia and higher risk of community acquired pneumonia. New drugs Famotidine and Nizatidine shown decrease stroke volume and also shows negative chronotropic effect. This anti ulcer activity was studied using different extracts of Carissa Carandas like Petether, Chloroform, Alcohol, Aqueous on different models of gastric ulcer, such as acetic acidinduce chronic gastric ulcer, pylorus ligation and ethanol induce acute gastric ulcer. These extract was administered orally with the dose of 500mg/kg. All extracts increased the healing of acetic acid induced chronic gastric ulcers (P< 0.05). But alcohol extract was more significant when it compare with standard (P< 0.001). In the case of pylorus ligation and stress induce ulcer showed significant anti ulcer activity (P< 0.05). So we conclude that alcoholic extract of Carissa Carandas shows more significant anti ulcer activity.

Keywords: anti-ulcer, Carissa carandas, acetic acid induce ulcer model, pylorus ligation.