PROTECTIVE ROLE OF LIV.52 AGAINST RADIATION AND CADMIUM INDUCED BIOCHEMICAL (SGOT/ SGPT) CHANGES IN THE SWISS ALBINO MICE
*Sharma Ramakant, and Rao Rakesh
ABSTRACT
The present study was aimed to evaluate protective efficacy of a
herbal drug Liv.52 against radiation and cadmium induced biochemical
changes in the Swiss albino mice. The animals treated with gamma
radiation and/or cadmium chloride with and without Liv.52 were
sacrificed by cervical dislocation at post treatment intervals of 1, 2,
4,7,14 and 28 days. The values of SGOT and SGPT found to increase
up to day-14 in non drug treated groups and day-7 in drug treated
groups. Thereafter a decrease in the value was observed without
reaching to the normal. When the animals were treated with radiation
and cadmium chloride simultaneously, synergistic effects were observed. In all drug treated
groups recovery started earlier than that in non drug treated groups. The Liv.52 treated
animals exhibited less severe damage and early recovery as compared to non drug treated
groups. Thus, it appears that Liv.52 is potent enough to check biochemical changes in the
Swiss albino mice.
Keywords: Radiation, Cadmium, Liv52, SGOT, SGPT, Mice.
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