FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF METFORMIN HYDROCHLORIDE BY USING DIFFERENT SYNTHETIC AND NATURAL SUPER DISINTEGRATING AGENT
Sumeet R. Sharma*,Ravindra N. Kamble, PukhrajShaikh, Shivam V. Joshi
ABSTRACT
Metformin HCl is an orally administered hypoglycemic agent, used in
the management of noninsulindependent diabetes. As precision of
dosing and patient’s compliance become important prerequisite for a
long term antidiabetic treatment, there is a need to develop formulation
for this drug which overcomes problems such as difficulty in
swallowing, inconvenience in administration while travelling and
patient’s acceptability. The purpose of the present study was to prepare
fast disintegrating tablets of metforminHCl in the oral cavity with
enhanced dissolution rate. The tablets were prepared with
Crosscarmilose sodium, Sodium starch glycolate, Pregelatinised starch
(synthetic superdisintegrant) and Isphagula husk, Mucilage of
Isphagula husk (natural superdisintegrant). The pure drug and formulation blend was
examined for angle of repose, bulk density, tapped density, Compressibility index and
Haussner’s ratio. The tablets were evaluated for hardness, tensile strength, drug content,
friability and were found satisfactory. All the dissolution parameters were calculated and
compared with market tablet increase in the dissolution rate was observed with F5
formulation.
Keywords: MetforminHCl, Orodispersible tablets, superdisintegrant, Direct compression.
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