ONE-POT SOLVENT-FREE SYNTHESIS, CYTOTOXICITY AND IN VITRO UREASE INHIBITORY ACTIVITY OF ZINC (II)-PIROXICAM COMPLEX
Muhammad Amin*
ABSTRACT
The solvent-free preparation and characterization of zinc(II)-piroxicam
complex, Zn-pir, is described. After comparison of the data of solventfree,
one-drop-solvent and solution products it was found that the
complex is of ML2 type. Zn-pir was found less toxic than parent drug
as evaluated by LD50 values. In Helicobacter pylori urease inhibitory
activity, Zn-pir showed significant inhibition. The results of this
investigation suggest that Zn-pir can be developed as a safer antiulcer
and anti-inflammatory agent.
Keywords: Piroxicam, Zinc complexes, NSAIDs, mechanochamical synthesis, urease inhibitory activity.
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