Abstract

STEPTOZOTOCIN INDUCED DIABETIC MICE MODEL FOR ANTIHYPERGLYCAEMIC ACTIVITY OF CITRULLUS COLOCYNTHIS LINN. FLOWERS

Dr. Vijay Nigam, Dr. Manoj Kumar Mishra and Pramod Kumar Biswal

ABSTRACT

The anti hyperglycaemic effect of aqueous extract of the flowers of Citrullus colocynthis Linn. in streptozotocin (STZ) induced diabetic mice. The flowers extract of Citrullus colocynthis Linn. in doses 100 and 200 mg/kg b.w was administered for 21 days and blood glucose level, serum cholesterol, liver glycogen was estimated. Treatment of the Streptozotocin induced diabetic mice with the flower extract resulted in significant reduction of blood glucose level (P<.0001), serum cholesterol (P<.01) and increase in liver glycogen (P<.0001). The results suggest that the flower extract of Citrullus colocynthis Linn possess anti hyperglycaemic effect in Streptozotocin induced diabetic mice which justify the traditional use of this plant as ethnomedicine in treatment of diabetes.

Keywords: Citrullus colocynthis Linn, Antihyperglycaemic, Diabetes mellitus, Streptozotocin, Oral administration.