Abstract

EVALUATION OF ORAL SUSTAINED DRUG DELIVERY OF CIPROFLOXACIN HYDROCHLORIDE LOADED SODIUM ALGINATE MICROSPHERES PREPARED BY IONOTROPIC GELATION TECHNIQUE

* Hemul V. Patel, Swati S. Vaza, Arvnabh Mishra, Mahendra M. Raj andNaynika K. Patel

ABSTRACT

Sustained-release polymeric beads containing Ciprofloxacin Hydrochloride fabricated with sodium alginate were prepared by the ionotropic gelation method. Model drug, ciprofloxacin hydrochloride was entrapped in sodium alginate in 1:1, 1:2, 1:2.5 and 1:3, ratios. Here, calcium chloride (5% and 10%) was used as a cross-linking agent. Beads of Ciprofloxacin hydrochloride were prepared with different concentrations of drug, polymers and electrolytes. The microbeads were characterized in terms of drug-excipent compatibility study, particle size analysis, shape analysis, drug content, encapsulation efficiency and in vitro drug release study. Results signified the fact that micro beads formed had sufficient good surface and size to be utilized as a dosage form responsible for sustained release of drug from matrix through erosion.

Keywords: Sustained release, Microbeads, Alginate, Ionotropic Gelation, Ciprofloxacin HCl