A RECENT REVIEW: JAPANESE ENCEPHALITIS
Hembade Mahendra*, Gaikwad Yogesh, Lukkad Harish, Kangane Monika, Dr. Sathesh Kumar
ABSTRACT
Japanese encephalitis (JE) is the most common form of viral
encephalitis that appears in the form of frequent epidemics of brain
fever throughout Southeast Asia, China and India. The disease is
caused by a Flavivirus named Japanese encephalitis virus that is spread
to humans by mosquitoes., Union health minister Ghulam Nabi Azad
launched India’s first indigenously prodcued vaccine against Japanese
Encephalitis (JE), a mosquito-borne viral infection that affects the
central nervous system. Bharat Biotech launch of its Vero cell-derived
purified inactivated JE vaccine “JENVAC™” which received the manufacturing and
marketing approvals by Drug Controller General of India (DCGI). It is a fully indigenous
vaccine commercialized using strain, identified, characterized, manufactured and tested in
India. JENVAC is a purified Inactivated Japanese Encephalitis vaccine produced from an
Indian thermally stable strain, 821564-XY.JENVAC® is indicated for the prevention of
disease caused by Japanese encephalitis virus (JEV) in persons 1 year of age and older. It is a
Vero cell derived, inactivated, and chromatographically purified Japanese encephalitis
vaccine and is made from a thermally stable India strain, Kolar, 821564-XY. The vaccine
must be administered intramuscularly. JENVAC is the first vaccine to be manufactured in the
public-private partnership mode. These new candidate JE vaccines have the potential to
generate long-lasting immunity at low cost.
Keywords: Encephalitis, JENVAC, vaccine.
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