Abstract

SYNTHESIS AND SEDATIVE-HYPNOTIC ACTIVITY OF NOVEL SERIES OF ISATIN HYDRAZONE AND ISATIN THIOSEMICARBAZONE DERIVATIVES

K.Swathi*and M. Sarangapani

ABSTRACT

In the present work, some new 5-[2(3)-dialkylamino alkoxy] Indole 3- thiosemicarbazone 2-ones and 5-[2(3)-dialkylamino alkoxy] Indole 3- hydrazone 2-ones were prepared from 5-hydroxy isatin. The structures of the products were characterized by IR, NMR, MASS Spectral studies. Thus synthesized and characterized targeted compounds were further screened for their Sedative-Hypnotic activity by using Potentiation of Pentobarbitone induced Narcosis method. Among all the newly synthesized derivatives, Compound IIIa, IIIb and Compound Va,Vb potentiated the sedative-hypnotic activity very significantly , thus these compounds showed promising activity and compounds IIIb and Vb showed moderate sedative-hypnotic activity.

Keywords: Synthesis, 5-[2(3)-dialkyl amino alkoxy] Indole 3-hydrazone 2-one, 5-[2(3)- dialkylamino alkoxy] Indole 3-thiosemicarbazone 2-ones, Sedative-Hypnotic Activity.