Abstract

REVIEW ON - BILAYER TABLET

Motarwar S.S.*, Jadhav S.B. ,Kadam V. S. , Muttepawar S.S, Bharkad V.B., Md. Zamiruddin

ABSTRACT

Over the past 30 years as the expense and complications involved in marketing new drug entities have increased ,with concomitant recognition of therapeutic advantages of controlled drug delivery, greater attention has been focused on development of sustained or controlled release drug delivery system.In the last decade interest in developing a combination of two or more active pharmaceutical ingredient(API)in a single dosage form(bilayer tablet)has increased in the pharmaceutical industry, promoting patient convenience and compliance. several pharmaceutical companies are currently developing bilayer tablet for a variety of reason: patentextension, therapeutic ,marketing to name a few. To reduce capital investment quite often existing but modified tablet presses are used to develop and such tablets. Bilayer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenacedose.Bilayer tablet is improved beneficial technology toovercome short coming of single layer tablet.

Keywords: Bilayer tablet, Approaches, Bilayer tablet presses, GMP requirement for Bilayer Tablets.