FORMULATION AND EVALUATION OF CANDESARTAN IMMEDIATE RELEASE TABLETS BY USING LIQUISOLID TECHNIQUE
P. Ujwala Reddy*, B.Venkateswara Reddy, K.Navaneetha
ABSTRACT
The aim of this study is to develop a novel liquid-solid technique to enhance the dissolution rate of poorly water soluble drug of candesartan, which is a BCS class II drug. The technique is based upon the admixture of drug loaded solutions (or) liquid drug with appropriate carrier and coating materials to convert into acceptably flowing and compressible powders. Addition of the additives improves the technique. The selection of non-toxic hydrophilic solvent, carrier, coating excipients and its ratios are independent of the individual chemical entities. Indirectly it leads to enhancement of bioavailability. Liquisolid tablets were prepared by using PEG -400, PG as non volatile liquid vehicles and Avicel PH 102, Aerosil 200 as carrier and coating materials, CCS as super disintegrants respectively. FTIR and DSC studies revealed that there was no possible interaction between drug and tablet excipients. All the formulations were evaluated for disintegration time, hardness and friability time, in-vitro dissolution study. Among all the formulations F7 was considered to be the best formulation, which release up to 98.1% of the drug in 60 mints.
Keywords: Candesartan, Liquisolid, PEG 400, PG, Aerosil, Avicel, Dissolution time, FTIR.
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