DETERMININATION OF PARTITION COEFFICIENT OF SALICYLIC ACID BETWEEN N-OCTANOL AND DISTILLED WATER
Singh Surya Pratap*, Kushwah Vivek, Rathore Puneet, Jain Pritam, Jaiswal Satish
ABSTRACT
The purpose of this paper is for introduction of partition co-efficient
that actually means to provide an estimate of the degree of drug
absorption and distribution within the body (lipid phase/aqueous
phase), the partition coefficient (in terms of logP) of the permeant
molecules is usually measured. n-octanol and water or a buffered
aqueous solution.Partition co-efficient is important physico-chemical
properties that are used in predict the diffusion of the drugs. Partition
co-efficient is defining as a ratio of un-ionised drugs of distribution
between the organic (oil phase) and aqueous phase. Partition
coefficient is higher better then its solubility.Partition coefficient is
measurement of drugs lipophilicity & indicator of its abilities to cross
cell membrane is oil/water partition co-efficient in system such as octanol/water and
chloroform /water.Although, Partition co-efficient data does not provides understanding of in
vivo absorption, it does provides a means character sizing lipophilicity & hydrophilicity
nature of drugs.
Keywords: Organic & Aaqueous phase, Lipophilicity, Hydrophilicity, Partition co-efficient.
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