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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

SPECTROPHOTOMETRIC ESTIMATION OF AMBROXOL HYDROCHLORIDE IN BULK AND TABLET FORMULATION

Suma.B.V.*, Kannan.K, Madhavan. V, Chandini R Nayar

ABSTRACT

A simple and sensitive spectrophotometric method in visible region has been developed for the estimation of ambroxol hydrochloride in bulk drug and in tables. In this method the free amino group of ambroxol hydrochloride reacts with ninhydrin reagent in alkaline medium to form a violet color chromogen which is determined spectrophotometrically at 567 nm. The optimum experimental condition for effect of heating, concentration of ninhydrin reagent and buffers were determined. It obeyed the Beer’s law range 2-10μg/ml. Percentage purity of drug in formulation by this proposed method was found to be 99.60%. The proposed method was found to be simple, accurate and precise method for routine estimation of ambroxol hydrochloride in bulk and from tablet dosage form.

Keywords: Ambroxol hydrochloride, ninhydrin, spectrophotometric.

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