Abstract

SYNTHESIS, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL CARBOXAMIDE DERIVATIVES OF NAPROXEN

*Jennifer Fernandes, Abhishek Kumar, Pankaj Kumar, Satyajeet Singh, Bhatt Meet, Bhakta Raju and Jain Mahaveer

ABSTRACT

A series of novel substituted 2-(6-methoxynaphthalen-2-yl)-Nphenylpropanamide (NAJ1-NAJ8) have been synthesized upon refluxing 2-(6-methoxynaphthalen-2-yl) propanoic acid with different substituted anilines in the presence of dry redistilled pyridine and silicon tetrachloride as coupling reagent. The structures of the final synthesized compounds were confirmed by IR, 1H NMR and mass spectra. The synthesized compounds were screened for their antibacterial and anti-inflammatory activities. The synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa by cup plate method. Compounds NAJ2, NAJ3, NAJ4 and NAJ5 showed good antibacterial activity compared to the standard drug ciprofloxacin. Thus some of the amide prodrugs of naproxen showed good antibacterial activity compared to the parent drug naproxen. The synthesized compounds were screened for their anti-inflammatory activity by Carrageenan induced paw edema method. The amide prodrugs of naproxen NAJ1, NAJ3, NAJ4 and NAJ8 showed significant anti-inflammatory activity compared to the standard drug naproxen.

Keywords: Naproxen, amide prodrugs, antibacterial activity, anti-inflammatory activity.