PROTECTIVE EFFECT OF Mussaenda frondosa Linn EXTRACTS ON ISONIAZID INDUCED HEPATOTOXICITY IN WISTAR RATS
Dr. Sambrekar Sudhir N.* and Dr. Patil Suhas A
ABSTRACT
The present study was undertaken to investigate the protective effect
and possible mechanism of alcoholic (AlE) and aqueous extract (AqE)
from Mussaenda frondosa Linn leaf (MF) on Isoniazid (INH)-induced
hepatic injury in Wistar rat. Hepatotoxic parameters studied in vivo
include serum transaminases (AST, and ALT, ALP), bilirubin, protein,
lipid profile (Cholesterol, triglyceride, VLDL and HDL) and level of
antioxidants together with histopathological examination. Liv 52® was
used as a reference hepatoprotective agent (5ml/kg-1b.w.). AlE and
AqE (200 mg/kg-1b.w.) on oral administration decreased the level of
AST, ALP, ALT, bilirubin, cholesterol, triglyceride, VLDL, MDA and
increased the level of protein, HDL and antioxidants (SOD, GSH and
CAT) in rats being treated with isoniazid (INH). Pentobarbitone -induced sleeping time study
was carried out to verify the effect on microsomal enzymes. Histopathological observations
confirmed the beneficial roles of MF against INH-induced liver injury in rats. Possible
mechanism may involve their antioxidant activity.
Keywords: Mussaenda frondosa Linn, hepatoprotective, Isoniazid, Liv 52®, sleeping time.
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