FORMULATIONS OF SUSTAINED RELEASE MATRIX TABLETS OF FUROSEMIDE USING NATURAL AND SYNTHETIC POLYMERS
Dr. D. Nagendrakumar, Reddy VM, Keshavshetti G G1, Shardor A G*
ABSTRACT
The primary benefit of a sustained release dosage form compared to a
conventional dosage form, is the uniform drug plasma concentration
and therefore uniform therapeutic effect. Matrix system are favored
because of their simplicity, patient compliance etc, than traditional
drug delivery which have many drawbacks like repeated
administration, fluctuation in blood concentration level etc. The
objective of the present study was to develop, evaluate and compare
once-daily sustained release matrix tablets of furosemide using
hydroxypropyl methylcellulose K4M and xanthan gum. The matrix
tablet formulations were prepared by using different drug: polymer
ratios (1:1, 1:2, 1:3, 1:4 and 1:5). The prepared matrix tablets were
evaluated for various parameters like hardness, thickness, weight
variation, friability, percent drug content and in vitro drug release studies as per USP
guidelines. Out of 10 formulations, the formulation SX1 is selected as best formulation which
shows 76.23 % drug release in 12 hrs.
Keywords: Furosemide, Hydroxypropyl Methylcellulose K4M, Xanthan gum, Sustained release matrix tablets etc.
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