FORMULATION AND STABILITY STUDIES OF AMOXYCILLIN AND POTASSIUM CLAVULANATE CHEWABLE TABLET
Monika Sharma*, Jugaldas Chudasama, Prabhu Narayan, and Pratap Singh Rathore, Ashok Kumar Sharma
ABSTRACT
Amoxycillin/Clavulanic acid or co-amoxiclave is a combination
antibiotic consisting of amoxycillin trihydrate, a β-lactam antibiotic,
and potassium clavulanate, a β-lactamase inhibitor. This combination
results in an antibiotic with an increased spectrum of action and
restored efficacy against amoxycillin-resistant bacteria that produce β-
lactamase. 10 formulation of the amoxycillin and potassium
clavulanate chewable tablet are formed with increasing or decreasing
the conc. of disintegrant and diluents. These formulations are formed,
evaluated and study accelerated stability studies for the best
formulation .Accelerated stability studies of amoxycillin and potassium
clavulanate chewable tablet was performed as per ICH guidelines. Various parameters are
analyzed including description, assay, dissolution, water content, and microbiological quality.
These parameters were evaluated at 0 month, 1 month, 2 month, 3 month and 6 month
intervals.
Keywords: Amoxycillin Trihydrate, Potassium Clavulanate, Accelerated stability studies, Chewable tablet, Dissolution study.
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