FORMULATION, DESIGN AND CHARACTERIZATION OF MICROEMULSION BASED SYSTEM FOR TOPICAL DELIVERY OF ANTIPSORIATIC DRUG
Nirmal Shah*, Avinash Seth, Sachin Chauhan, Chintan Aundhia, Ankur Javia, Girish Sailor
ABSTRACT
The purpose of this study was to develop a stable methotrexate (MTX)
loaded microemulsion gel (MMG) for topical use in psoriasis to
improve cutaneous deposition and local effect. The pseudo-ternary
phase diagrams were developed for various microemulsion
formulations composed of Capmul MCM - C8 as oil phase, Tween 20
as surfactant and polyethylene glycol 400 (PEG 400 as cosurfactant.
Composition of microemulsion system was optimized using
concentration of oil, surfactant/cosurfactant (1:1) and water as
independent variables. The MTX- loaded microemulsion was
characterized by droplet size and zeta potential. Microemulsion gel
was prepared by adding 1% Carbopol 934 as a gelling agent. The
transdermal ability of MTX from microemulsion gel was evaluated by
in vitro permeation study. The results shows that optimized
microemulsion formulation was composed Capmul MCM - C8 (7.5% w/w), Tween 20
(37.5% w/w), PEG 400 (12.5% w/w) and water (42.5% w/w). The optimized microemulsion
was found to be relatively uniform in size of optimized (11.52 ± 0.6 nm). The MMG showed
enhanced in vitro permeation ability with better drug deposition capacity compared MTX
solution, gel and microemulsion. The results suggest that the MMG is promising formulation
for topical delivery of MTX for psoriasis treatment.
Keywords: Methotrexate; Microemulsion; Microemulsion gel; Topical delivery; Antipsoriatic.
[Download Article]
[Download Certifiate]