TUBERCULOSIS IS ASSOCIATED WITH LOW LEVELS OF VITAMIN D
*Dr.Mrinal Pal, Dr.Subinay Datta, Dr.Ritabrata Mitra
ABSTRACT
Introduction: Tubercular patients may be at increased risk for vitamin
D deficiency, but risk factors for deficiency among COPD patients
have not been extensively reported. Methods: Serum 25(OH)D was
estimated by enhanced chemiluminescent assay in subjects aged 20-60
years from Burdwan Medical College, Burdwan, West Bengal, India,
including 552 tubercular patients and 521 controls. Levels 20 ng/ml
defined deficiency. Season, sex, age, diets, body complexion, body
mass index (BMI), smoking, comorbidities (Charlson score), were
examined for associations with 25(OH)D in both linear and logistic
regression models. Results: Tubercular patients had an increased risk
for vitamin D deficiency compared to controls after adjustment for age,
smoking and BMI, season, diet, skin complexion. Variables associated with lower 25(OH)D
levels in tubercular patients were obesity ( -6.65), current smoking ( -4.09), Vegetarian (-
3.94), dark skin complexion (-1.58) and depression ( -3.26). Summertime decreased the risk
of vitamin D deficiency (OR = 0.24). Conclusion: Tuberculosis was associated with an
increased risk of vitamin D deficiency even after adjustment for confounding factors that are
responsible for lowering vitamin D.
Keywords: Tuberculosis, 25 (OH) D, Confounding factors.
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