ANTI-ARTHRITIC ACTIVITY OF EUPHORBIA THYMIFOLIA LINN
G.C. Mamatha*, T.Prabhakar, V. Madhuri, K. Neelima, E. Venkatanagaraju and S.B.Chandrasekar
ABSTRACT
Euphorbia thymifolia Linn; (Euphorbiaceae) is a small prostate,
hispidly pubescent, annual weed, which is commonly found in India
and tropical countries. It is believed to possess Diuretic, Laxative, and
Detumescent, anti-malarial, anti-diarrheic, anti-rash, anti-dysentery,
anti-carbuncle detoxification and anti-hemorrhoidal activity and also
reported to be used in the treatment of aches and pains etc. The aim of
present study was to evaluate the anti-arthritic activities of whole plant
of Euphorbia thymifolia Linn using Freund’s adjuvant-induced arthritis
in rats. Petroleum ether (40-60°C), Chloroform, Alcohol, Aqueous
extract of Euphorbia thymifolia were tested for various preliminary
phytoconstituents and were screened for anti-arthritic activities using
Freund’s adjuvant arthritis in albino rats. The extracts were
administered orally for 21 days and the mean changes in diameter of paw were noted at
regular intervals. On 22nd day at the end of study blood was collected and hemoglobin
content, total WBC count, Differential WBC count, ESR, RBC, SGOT, SGPT, ALP, TP,
Lipid peroxidation in liver and effect of gastric mucosa were also estimated. From the results
obtained in the current investigation, it may be concluded that the Euphorbia thymifolia Linn
possess anti-arthritic activity.
Keywords: Euphorbia thymifolia, anti-arthritic, adjuvant arthritis
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