ONE POT GREEN SYNTHESIS OF 2-ARYL/HETERYLBENZIMIDAZOLE AS ANTI-INFLAMMATORY AGENTS
Anna Pratima Nikalje*, Mangesh Ghodke
ABSTRACT
Benzimidazole derivatives constitute an interesting class of organic
compounds with diverse pharmacological activities. In view of the
observations and in continuation of previous synthetic programme on
the synthesis of chalcones and their derivatives, present study report
the synthesis of some new benzimidazole derivatives which have been
found to possess an interesting profile of anti-inflammatory activity.
The present study reports an eco-friendly, one pot, microwave-assisted
expeditious synthesis of 2-aryl/heteryl-substituted benzimidazole
derivatives and their anti-inflammatory activity. The one pot synthesis
was carried out under microwave irradiation, by condensing phenylene
diamine with aryl and/or heteryl aldehydes in solvent-free conditions
using zirconium oxy chloride as catalyst in borosil beaker and
irradiated in synthetic microwave oven at 700W for 3-6 min. The
reaction was carried out at 700C- 850C.The products were obtained in good yields and in
shorter reaction times. The synthesized compounds were evaluated for in-vivo antiinflammatory
activity on Wistar albino rats in carrageenan induced rat paw edema model.
After 1hr compound no. 3e, after 2hr compound no. 3b, 3d and after 3hr compound no. 3d,
3e and 3h have exhibited more percentage of inhibition of anti-inflammatory activity.
Keywords: Green synthesis, eco friendly, benzimidazole, carrageenan, anti-inflammatory activity, indomethacin.
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