Abstract

ANTITUMOUR ACTIVITY OF HIBISCUS ROSA-SENENSIS

D.Peer Basha, K.Ravishankar, G.V.N.Kiranmayi, Subbarao.M*

ABSTRACT

Traditional medicine has a long history of serving peoples all over the world. India is without doubt a herbal hub. Medicinal plants that are native to India and their use in various traditional systems of medicine are indeed awe-inspiring. The ethnobotany and ubiquitous plants provide a rich resource for natural drug research and development. In recent years, the use of traditional medicine information on plant research received considerable interest. In the present study, twenty one plant extracts of different species used by Indian traditional healers for the treatment of ulcers, cancers, tumors, warts, and other diseases, were tested in vitro for their potential anticancer (Antiproliferative and cytotoxic) activity. The aqueous leaf extract of Hibiscus rosa-sinensis was tested against four human cancer cell lines using MTT 3-(4,5-dimethylthiazol–2-yl)- 2,5-diphenyltetrazolium bromide and found to be active anticancerous agents .The results obtained from the Phytochemical analysis and the cytotoxic activity of this plant revealed that further investigations may lead to the development of potent anticancer agents from H. rosa sinensis. The present finding may pave the way for the bioactivity guided fractionation and isolation of important moieties for the anticancer chemotherapy and in part help to minimize the serious lacuna in scientific validation of these herbs.

Keywords: Hibiscus rosa-sinensis, antitumor activity, Traditional medicine, MTT.