DESIGN AND EVALUATION OF OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM OF ANTI-HYPERTENSIVE DRUG LOSARTAN POTASSIUM
Motugatla. Prasad*, E. Bhavya, Vedachalam. Gunasekharan
ABSTRACT
The main objective of the present work is to develop a Novel
osmotically controlled drug delivery system of Losartan Potassium. It
was aimed to prepare for prolonged residence in the stomach over
conventional Gastro-retentive approaches. Losartan Potassium tablets
were prepared by direct compression method employing different
polymers like HPMC K4M, HPMC K15M, Carbopol 974P in different
proportions along with sodium bicarbonate as a gas generating agent.
FTIR and DSC studies showed that drug and polymers are compatible.
The prepared granules were evaluated for angle of repose,
compressibility index and hausner’s ratio and results obtained were
satisfactory compressed formulations were further evaluated for weight
variation, hardness, thickness, friability, buoyancy studies, drug
content and in-vitro dissolution studies. All the formulations showed good results which were
compliance with pharmacopoeial standards. Among all formulations HPMC K15M grade
provided better controlled release characteristics with excellent drug release and buoyancy.
Among all formulations it was concluded that the formulations with K15M is optimized for
better release, and FM 8 formulation is optimized among the K15M formulations because of
its equal combination of osmotically controlled polymer and hydrophilic polymer.
Keywords: Osmotically controlled drug delivery, Losartan potassium, HPMC K15M, Direct compression, Buoyancy studies.
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