SYNERGISTIC ACTIVITY OF BARK EXTRACTS OF PONGAMIA GLABRA AND FICUS GLOMERATA IN ALLOXAN-INDUCED DIABETIC RATS
Sanjeev Heroor*, Arunkumar Beknal1, Nitin Mahurkar
ABSTRACT
Polyherbal therapy is said to be a better choice in the treatment of
diabetes mellitus having the advantage of producing maximum
therapeutic efficacy with minimal side effects. In the present study the
combination of low doses of methanolic extracts of Pongamia glabra
(PBME) and Ficus glomerata (FBME) was subjected for determination
of its antihyperglycemic effects in comparison with their individual
treatments and a standard hypoglycemic agent, glibenclamide. The
effect of combination of extracts was evaluated in normal and alloxaninduced
diabetic rats using the parameters such as glucose tolerance
test, acute and sub-acute levels of antidiabetic study and body weight
estimations at various intervals. Glibenclamide was administered orally
at 600 μg/kg. PBME and FBME were individually administered at 100
(low dose) and 200 mg/kg (high dose) respectively. Combination of 100 mg/kg (low doses)
of PBME and FBME was also administered. Significant (P<0.01) hypoglycemic effect was
noticed with the combination therapy of low doses of PBME and FBME compared to their
individual treatments at both doses and glibenclamide in the parameters studied and it was
also able to produce more percentage increase in body weight than the individual treatments.
It is concluded from the study that the combination therapy of low doses of PBME and
FBME showed synergistic antihyperglycemic effect. This could provide an opportunity to
reduce the dose of antidiabetic herbal drugs to achieve an enhanced therapeutic effect with
minimal side effects.
Keywords: Polyherbal therapy, Pongamia glabra, Ficus glomerata, glibenclamide, hypoglycemic effect.
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