IN VITRO ANTIPLASMODIAL ACTIVITY OF SEAWEED ASSOCIATED ACTINOMYCETES AGAINST PLASMODIUM FALCIPARUM
M. Babuselvam*, S. Ravikumar, S. Abideen, M. Peer Mohamed and H.S. Muthu Mohamed
ABSTRACT
The present investigation reported that, the screening of actinomycetes
isolated from the seaweeds of Palk Strait for production of antimalarial
comounds. The actinomycetes were cultured using starch casein agar
and secondary metabolites obtained using ethyl acetate. Thereafter,
the assay was employed to evaluate the impact of these metabolites on
the growth of Plasmodium falciparum. The method was used to
determine the parasite inhibition profiles and 50% inhibitory
concentration values of the actinomycetes crude extracts. Out of 3
tested crude extract of actinomycetes, third (ACT-3) crude extract
showed strong growth inhibition with an IC50 in the low microgram
range (35.48 μg mL-1). The results were found to be potential for more
comprehensive studies on new antimalarials from seaweed associated
actinomycetes.
Keywords: Actinomycetes, seaweed, anti-malaria, bioactive compounds.
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