ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF FICUS AURICULATA LOUR. LEAF EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC MICE
Rosalind Thingbaijam*, Biman Kumar Dutta & Satya B. Paul
ABSTRACT
Objective: Antihyperglycemic and antihyperlipidemic activity of
Ficus auriculata Lour. leaf extract in streptozotocin induced diabetic
mice. Materials and Methods: Diabetes was induced in swiss albino
mice by administration of streptozotocin (70 mg/kg, i.p.). Normal as
well as diabetic albino mice were divided into groups (n = 6) receiving
different treatments: vehicle (control), methanol extract (300 and 600
mg/kg b.w), and standard antidiabetic drug glibenclamide (10 mg/kg
b.w.). Blood samples were collected from tail for blood glucose
analysis on (0th, 5th, 10th and 15th day) and animals were sacrificed on
15th day and blood sample were collected by cardiac puncture and
analyzed for lipid profile. Histological studies were done on pancreas
and liver respectively. Results: The methanol extract of Ficus
auriculata Lour. produced significant reduction ( P < 0.001) in blood
glucose and also had beneficial effects ( P < 0.05) on the lipid profile in streptozotocin
induced diabetic mice at the end of the treatment period (15th day). The histopathological
studies have shown to ameliorate the streptozotocin induced histological damage of islets of
langerhands in pancreas and hepatocytes in liver. Conclusion: We concluded that methanol
extract of Ficus auriculata Lour. is effective in controlling blood glucose levels and improves
lipid profile in streptozotocin induced diabetic mice.
Keywords: Antihyperglycemic, antihyperlipidemic, Ficus auriculata Lour., glibenclamide, histopathological, streptozotocin.
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