IN SITU GEL-NOVEL APPROACH FOR NASAL DELIVERY
J.U.Kute*, A. B. Darekar, R.B. Saudagar
ABSTRACT
Nasal delivery is a feasible alternative to oral or parenteral
administration for some Drugsbecause of the high permeability of the
nasal epithelium, rapid drug absorption acrossthis membrane and
avoidance of hepatic first-pass metabolism. Besides this, intranasal
routehas also been successfully exploited for bypassing the blood brain
barrier and subsequentlydelivering drug molecules to central nervous
system. In addition it minimizes the lag time associated with oral drug
delivery and offers noninvasiveness, self-medication, patient comfort
and patient compliance. Prolonged drug delivery can be achieved by
various new dosage forms like in situ gel. In situ forming polymeric
formulations are drug delivery systems. That is in sol form before
administration in the body, but once administered, undergoes gelation,
in situ to form a gel. In situ gelling systems are liquid at roomtemperature but undergo
gelation when in contact with body fluids or change in pH in situ gelforming drug delivery is
a type of mucoadhesive drug delivery system. Now a day in situ gel has been used as vehicle
for the drug delivery of the drug for both local treatment and systemic effect. In situ gelling
system becomes very popular nowadays because of their several advantages
overconventional drug delivery systems like sustained and prolonged release of drug, reduced
Frequency of administration, improved patient compliance and comfort.
Keywords: In Situ Gel, Gelation, Mucoadhesive.
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