Abstract

HIGHLY PURIFIED FENUGREEK GUM BASED SILICA LIPID SYSTEM FOR SIMVASTATIN: IN VIVO STUDY

Ajay Kumar Sav¹*, Gauresh Somani¹ and Purnima Dhanraj Amin¹

¹Department of Pharmaceutical Sciences and Technology, Institute of ChemicalTechnology, N. P. Marg, Matunga, Mumbai - 400019, India.

ABSTRACT

The objective of current study was to investigate anti-hyperlipidemic activity of previously developed highly purified fenugreek gum based silica lipid systems for Simvastatin in poloxamer F127 induced hyperlipidemic rats. For the preparation of highly purified fenugreek gum based silica lipid system, three different grades of silica like Aerosil 300 Pharma, Aerosil 380 Pharma and Aeroperl 300 Pharma were used as hydrophilic solid carriers. Highly purified fenugreek gum as emulsifier and Camplul MCM as oil lipid phase was used. The test samples were administered orally at a dose of 1mg/kg body weight to the poloxamer F-127 induced hyperlipidemic rats and total cholesterol, triglyceride, HDL and VLDL level in the blood were checked. All the three optimized showed significant reduction (P<0.05) in comparison with standard Simvastatin. From the study it could be concluded that developed silica lipid systems has significant effect on cholesterol, VLDL, triglyceride and HDL level as compared to plain Simvastatin.

Keywords: Silica lipid system, Simvastatin, antihyperlipidemic, poloxamer F-127.