Abstract

MODIFIED FENUGREEK GUM FOR SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT OF SIMVASTATIN

Ajay Kumar Sav*¹, Ritesh Fule¹, Kailas Moravkar¹, Purnima Dhanraj Amin¹

¹Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology,N. P. Marg, Matunga, Mumbai 400019, India.

ABSTRACT

Simvastatin is a hypolipidemic BCS class II drug and has poor bioavailability due to low aqueous solubility. Solid dispersion is the one of the most promising method for improving the water solubility and therefore the drug bioavailability. In this study, solid dispersion of Simvastatin was prepared using lab synthesized hydrophilic surface active polymer octenyl succinate fenugreek gum as a carrier by cosolvent precipitation method. Different batches of solid dispersion were prepared in varying drug polymer ratio. Prepared solid dispersions were evaluated for solubility and dissolution rate. It was found that solid dispersion prepared from drug polymer 1:0.1 weight ratio showed threefold increase in dissolution rate and solubility was also improved several fold in dissolving medium. Solid dispersion was characterized for physicochemical property by differential scanning calorimetry, scanning electron microscopy, FTIR and particle size distribution. The compilations of these results revealed that increase in surface wet ability by hydrophilic carrier responsible for the dissolution rate enhancement.

Keywords: Simvastatin, fenugreek gum, solid dispersion, dissolution rate.